Antipsychotics primarily affect dopamine transmission at which receptor site?

Antipsychotics primarily target the dopamine type 2 (D2) receptor site because these receptors play a significant role in the pathways associated with mood, cognition, and psychosis. The blockade of D2 receptors is critical in treating symptoms of schizophrenia and other psychotic disorders. When D2 receptors are inhibited, it leads to a reduction in dopaminergic overactivity, which is often implicated in the positive symptoms of psychosis, such as hallucinations and delusions.

By effectively blocking D2 receptors, antipsychotics help correct the imbalance of dopamine that contributes to these symptoms. This mechanism of action is a cornerstone in the pharmacological management of psychosis, making the D2 receptor a primary target in antipsychotic therapy. Additionally, the effectiveness of different antipsychotics may vary based on their affinity for D2 receptors and their ability to influence other receptor sites, but the D2 receptor remains central in their therapeutic effects.