What class of antidepressants is commonly used to treat PTSD?

Selective serotonin reuptake inhibitors (SSRIs) are the class of antidepressants that are commonly used to treat post-traumatic stress disorder (PTSD). Numerous clinical studies have shown SSRIs to be effective in reducing symptoms of PTSD such as intrusive thoughts, avoidance behaviors, and emotional numbness. They work by increasing the level of serotonin in the brain, which can help improve mood and anxiety by balancing neurotransmitters associated with these conditions.

SSRIs, including medications such as sertraline and paroxetine, have been specifically approved for the treatment of PTSD, highlighting their established role in clinical practice. Their relatively favorable side effect profile compared to other classes of antidepressants and their efficacy in alleviating the core symptoms of PTSD make them the first-line pharmacological treatment for this disorder.

In contrast, while tricyclic antidepressants (TCAs) may be used for various mood disorders, they are not considered first-line treatments for PTSD due to their side effect profile and fewer supporting studies compared to SSRIs. Monoamine oxidase inhibitors (MAOIs) are less commonly used as well, primarily due to their dietary restrictions and side effects. Stimulants are generally not used to treat PTSD and are instead more commonly associated with the treatment of attention-def