What is the therapeutic level of valproic acid used as a mood stabilizer?

The therapeutic level of valproic acid, commonly used as a mood stabilizer, is recognized to fall within the range of 50 to 100 mcg/mL. This range is crucial for achieving optimal therapeutic effects while minimizing the risks of toxicity. Valproic acid is primarily utilized in the treatment of bipolar disorder and epilepsy and works by increasing the availability of gamma-aminobutyric acid (GABA) in the brain, which helps to stabilize mood.

Maintaining serum levels within this therapeutic range is essential for ensuring that the medication is effective in managing symptoms of mood disorders. Levels below 50 mcg/mL may be insufficient for therapeutic efficacy, leading to increased symptoms of mania or depression, while levels above 100 mcg/mL heighten the risk of adverse effects such as hepatotoxicity, pancreatitis, and neurological disturbances.

Close monitoring of valproic acid levels in patients is necessary to adjust dosages and ensure that the medication is both safe and effective.