Which class of antidepressants is known for being the least sedating and having lower rates of orthostatic hypotension?

Selective Serotonin Reuptake Inhibitors (SSRIs) are recognized for their relatively favorable side effect profile compared to other classes of antidepressants. One of the key characteristics of SSRIs is that they tend to be less sedating than tricyclic antidepressants (TCAs) and MAOIs, which often have sedative effects due to their more generalized action on neurotransmitters. The lower rates of orthostatic hypotension associated with SSRIs make them a safer choice for patients who may be at risk for blood pressure-related complications. This feature is particularly beneficial in elderly populations or those with pre-existing conditions that may exacerbate hypotension. Overall, SSRIs' mechanism of selectively inhibiting the reuptake of serotonin enhances mood with a lower incidence of sedation and orthostatic effects, making them a first-line treatment option for depression and anxiety disorders.