Which class of drugs is associated with traditional dopamine antagonists?

First Generation Antipsychotics are indeed associated with traditional dopamine antagonists. This class of medications primarily works by blocking dopamine receptors in the brain, particularly the D2 receptor subtype. This mechanism is foundational in the management of psychotic disorders, such as schizophrenia, as it helps to decrease the symptoms associated with these conditions, including delusions and hallucinations.

The first-generation antipsychotics include drugs like haloperidol and chlorpromazine, which have been used for decades. Their action on dopamine pathways has been thoroughly studied and is a key element of their pharmacological profile.

In contrast, Second Generation Antipsychotics primarily target both dopamine and serotonin receptors, which can lead to a different side effect profile and potentially greater efficacy in certain patients. Selective Serotonin Reuptake Inhibitors and Tricyclic Antidepressants do not primarily act as dopamine antagonists but rather focus on the serotonin system and norepinephrine pathways, respectively. Thus, the categorization of First Generation Antipsychotics as traditional dopamine antagonists is well-founded in psychiatric pharmacology.