Which common side effect is associated with both Serotonin-norepinephrine Reuptake Inhibitors (SNRIs) and Tricyclic Antidepressants (TCAs)?

Drowsiness is a common side effect associated with both Serotonin-norepinephrine Reuptake Inhibitors (SNRIs) and Tricyclic Antidepressants (TCAs). This side effect can occur due to the medications’ impact on neurotransmitter levels and their sedative properties.

In the case of TCAs, they often have antihistaminic effects that contribute to sedation, making drowsiness a prominent side effect. Similarly, some SNRIs can also exert a sedative effect, especially when they influence norepinephrine and serotonin levels, leading to altered sleep patterns and daytime drowsiness.

Understanding this manifests in clinical practice is essential for managing patient care effectively, as awareness of potential drowsiness can help healthcare providers guide patients regarding when to take their medications, particularly if their daily activities require alertness.