Which drug class blocks approximately 65-80% of D2 receptor sites and can also treat depression with psychotic features?

The drug class that blocks approximately 65-80% of D2 receptor sites and can also treat depression with psychotic features is correctly identified as second generation antipsychotics. These medications are often referred to as atypical antipsychotics and are characterized by their ability to manage symptoms of schizophrenia and bipolar disorder, as well as to treat depressive disorders with psychotic features.

Second generation antipsychotics not only target D2 receptors but also affect a range of serotonin receptors, which contributes to their effectiveness in treating both psychotic and depressive symptoms. This dual action makes them particularly suitable in situations where a patient exhibits signs of depression accompanied by psychosis, as they can alleviate both the mood and psychotic symptoms.

In contrast, first generation antipsychotics primarily focus on D2 receptor blockade and are less effective for mood disorders, specifically depression. Atypical antidepressants do not primarily target the D2 receptors nor are they recognized for treating psychotic features. Tricyclic antidepressants, while useful for various types of depression, do not provide significant antipsychotic effects. This makes the second generation antipsychotics the most appropriate class for the question presented.