Which first-generation antipsychotic is known for calming and sedating patients in psychosis?

Chlorpromazine, marketed as Thorazine, is recognized for its calming and sedating properties, particularly in the treatment of psychosis. This first-generation antipsychotic is notable not only for its efficacy in managing symptoms of schizophrenia and acute psychosis but also for its sedative effects, which can help alleviate agitation and anxiety that often accompany these conditions.

The mechanism of action for chlorpromazine involves blockade of dopamine receptors, which reduces dopaminergic overactivity in the brain, a key factor in many psychotic disorders. The tranquilizing effects can be beneficial in acute settings where rapid sedation is necessary to ensure patient safety and comfort.

In contrast, other options, while being first-generation antipsychotics, do not carry the same level of sedative effect as chlorpromazine. Haloperidol, often used for its strong antipsychotic properties, is less sedating and more likely to cause extrapyramidal symptoms. Thioridazine does have some sedative effects, but chlorpromazine's efficacy in calming and treating acute psychosis is more pronounced. Clozapine, being a second-generation antipsychotic, primarily targets a different set of neurotransmitter systems and is not classified as a sedative in the same