Which medication class is known to increase the risk of depression?

Benzodiazepines are known to have a potential association with an increased risk of depression in some individuals. While these medications are primarily prescribed for anxiety and insomnia, their central nervous system depressant effects can lead to mood disturbances over time, particularly with prolonged use or in higher doses. Chronic use of benzodiazepines may interfere with the body's neurotransmitter systems, potentially exacerbating mood disorders such as depression.

In contrast, antipsychotics are typically used to manage conditions like schizophrenia and bipolar disorder, and while certain antipsychotics can have side effects that impact mood, they are generally not associated with increasing the risk of depression as a class.

Stimulants, which are primarily utilized in the treatment of attention-deficit/hyperactivity disorder (ADHD), may improve mood and focus, rather than contributing to depression.

Selective serotonin reuptake inhibitors (SSRIs) are commonly used antidepressants that aim to treat depression and anxiety by increasing serotonin levels in the brain and are not associated with an increased risk of depression. In fact, they are typically prescribed to alleviate depressive symptoms.

Thus, benzodiazepines stand out as the medication class that can potentially lead to an increased risk of depression, especially when used over a long period.