Which medication increases GABA and is known to enhance sleep duration but can intensify the effects of CNS depressants?

The medication that increases GABA and is known to enhance sleep duration while potentially intensifying the effects of CNS depressants is Zolpidem. Zolpidem is primarily a non-benzodiazepine hypnotic that acts on the GABA receptor, increasing GABAergic activity. This mechanism facilitates sleep induction and prolongs sleep duration, making it particularly effective for treating insomnia.

Zolpidem’s interaction with other central nervous system (CNS) depressants, such as alcohol or benzodiazepines, can lead to an additive effect, which may enhance sedation and respiratory depression, making use with these substances risky. This highlights the importance of careful monitoring and patient education regarding the use of Zolpidem with other CNS depressants.

Other medications listed, like Diazepam and Alprazolam, are benzodiazepines that also act on GABA receptors but are typically used for anxiety or muscle relaxation rather than strictly for enhancing sleep duration. Zaleplon, on the other hand, is a rapid-onset hypnotic that is less effective for maintaining sleep. Therefore, Zolpidem stands out as the medication specifically known for its primary use in enhancing sleep while increasing GABA activity.