Which medication is specifically indicated for treating nightmares associated with PTSD?

Prazosin is specifically indicated for treating nightmares associated with post-traumatic stress disorder (PTSD) due to its ability to block alpha-1 adrenergic receptors in the central nervous system. This action helps to diminish the intensity and frequency of nightmares, which are a common symptom experienced by individuals with PTSD. Research has shown that prazosin can lead to a significant reduction in the distressing dreams associated with the disorder, making it a preferred choice for this specific symptom.

Other medications mentioned, while having their own indications in mental health, do not target nightmares directly. Lamotrigine is primarily used for mood stabilization in conditions like bipolar disorder and epilepsy. Fluvoxamine is an SSRI used for obsessive-compulsive disorder and not specifically for nightmares or PTSD. Buspirone is primarily an anxiolytic for generalized anxiety disorder and is not indicated for the treatment of PTSD nightmares. Thus, prazosin stands out as the most appropriate and effective choice for addressing this particular symptom of PTSD.