Which of the following is NOT a First Generation Antipsychotic (FGA)?

Aripiprazole is classified as a Second Generation Antipsychotic (SGA) rather than a First Generation Antipsychotic (FGA). FGAs, also known as typical antipsychotics, primarily include medications that work by blocking dopamine receptors in the brain and have been used for many decades to treat psychosis, schizophrenia, and other mental health disorders. Examples of FGAs include Perphenazine, Fluphenazine, and Chlorpromazine, which all belong to this category and function primarily through dopamine antagonism.

In contrast, Aripiprazole operates differently by acting as a partial agonist at dopamine D2 receptors, which is characteristic of SGAs. Additionally, it has a more favorable side effect profile with a lower risk of extrapyramidal symptoms compared to FGAs, contributing to its distinct classification. This understanding is crucial for identifying the appropriate medication approaches in mental health treatment.