Which of the following is not a common Serotonin-norepinephrine Reuptake Inhibitor (SNRI)?

Imipramine is not classified as a Serotonin-norepinephrine Reuptake Inhibitor (SNRI). Instead, it is a tricyclic antidepressant (TCA) that primarily works by inhibiting the reuptake of serotonin and norepinephrine, but its mechanism and classification differ from that of SNRIs.

SNRIs, such as Venlafaxine, Duloxetine, and Desvenlafaxine, specifically target the dual inhibition of the reuptake of serotonin and norepinephrine in a more selective manner. This differential targeting often results in distinct pharmacological profiles and side effect profiles when compared to tricyclic antidepressants like imipramine. Understanding the classifications and mechanisms of these medications is crucial for selecting appropriate treatment options in clinical practice.