Which of the following is a notable side effect of Tricyclic Antidepressants (TCAs)?

Tricyclic Antidepressants (TCAs) are known to have a range of side effects, and dry mouth is particularly notable among them. This side effect occurs due to the anticholinergic properties of TCAs, which inhibit the action of acetylcholine—a neurotransmitter that plays a significant role in stimulating saliva production. The resulting decrease in saliva can lead to discomfort and increase the risk of dental issues over time.

While increased perspiration, nausea, and anxiety can also occur with TCAs, dry mouth is more consistently recognized as a significant side effect directly associated with their use. Understanding the pharmacological actions of TCAs helps clarify why dry mouth is distinctly noteworthy, as it can significantly impact a patient's quality of life and willingness to continue treatment. Additionally, the management of this side effect often requires careful consideration and sometimes additional interventions to mitigate discomfort for patients on TCAs.