Which of the following symptoms is NOT associated with Neuroleptic Malignant Syndrome?

Neuroleptic Malignant Syndrome (NMS) is a serious and potentially life-threatening reaction to antipsychotic medications, characterized by a specific set of symptoms. Among these, increased creatine phosphokinase (CPK) levels, leukocytosis, and altered mental status are all commonly recognized symptoms associated with NMS.

Increased CPK levels result from muscle rigidity and breakdown, which are hallmark features of NMS. Leukocytosis, or an elevated white blood cell count, can occur in response to the stress and inflammation induced by the syndrome. Altered mental status, which can range from confusion to coma, is also a critical symptom often observed in patients experiencing NMS.

In contrast, a shuffling gait is not a recognized symptom of NMS. While it can be associated with other neurological conditions or side effects of certain medications, it does not characterize the acute and severe response seen in NMS. Therefore, identifying that a shuffling gait does not fall within the spectrum of symptoms typically associated with Neuroleptic Malignant Syndrome makes it the correct answer in this context.